APOBEC enzymes as targets for virus and cancer therapy
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements
YL Chiu, WC Greene - Annu. Rev. Immunol., 2008 - annualreviews.org
All retroviruses, including HIV-1, display species-specific patterns of infection. The impaired
growth of these retroviruses in foreign and sometimes even in their natural hosts often stems …
growth of these retroviruses in foreign and sometimes even in their natural hosts often stems …
The APOBEC3 family of retroelement restriction factors
EW Refsland, RS Harris - Intrinsic immunity, 2013 - Springer
The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …
APOBEC3 proteins in viral immunity
S Stavrou, SR Ross - The Journal of Immunology, 2015 - journals.aai.org
Apolipoprotein B editing complex 3 family members are cytidine deaminases that play
important roles in intrinsic responses to infection by retroviruses and have been implicated …
important roles in intrinsic responses to infection by retroviruses and have been implicated …
HIV-1 Vif, APOBEC, and intrinsic immunity
R Goila-Gaur, K Strebel - Retrovirology, 2008 - Springer
Members of the APOBEC family of cellular cytidine deaminases represent a recently
identified group of proteins that provide immunity to infection by retroviruses and protect the …
identified group of proteins that provide immunity to infection by retroviruses and protect the …
APOBEC proteins and intrinsic resistance to HIV-1 infection
MH Malim - … Transactions of the Royal Society B …, 2009 - royalsocietypublishing.org
Members of the APOBEC family of cellular polynucleotide cytidine deaminases, most
notably APOBEC3G and APOBEC3F, are potent inhibitors of HIV-1 infection. Wild type HIV-1 …
notably APOBEC3G and APOBEC3F, are potent inhibitors of HIV-1 infection. Wild type HIV-1 …
Functions and malfunctions of mammalian DNA-cytosine deaminases
The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils,
causing base substitutions and strand breaks. They are induced by cytokines produced …
causing base substitutions and strand breaks. They are induced by cytokines produced …
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G
D Pollpeter, M Parsons, AE Sobala, S Coxhead… - Nature …, 2018 - nature.com
Following cell entry, the RNA genome of HIV-1 is reverse transcribed into double-stranded
DNA that ultimately integrates into the host-cell genome to establish the provirus. These …
DNA that ultimately integrates into the host-cell genome to establish the provirus. These …
The role of cytidine deaminases on innate immune responses against human viral infections
The APOBEC family of proteins comprises deaminase enzymes that edit DNA and/or RNA
sequences. The APOBEC3 subgroup plays an important role on the innate immune system …
sequences. The APOBEC3 subgroup plays an important role on the innate immune system …