The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Barriers and strategies of cationic liposomes for cancer gene therapy

C Liu, L Zhang, W Zhu, R Guo, H Sun, X Chen… - … Therapy Methods & …, 2020 - cell.com
Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors
for decades with the advantages of excellent biodegradability, biocompatibility, and high …

Cloaking nanoparticles with protein corona shield for targeted drug delivery

JY Oh, HS Kim, L Palanikumar, EM Go, B Jana… - Nature …, 2018 - nature.com
Targeted drug delivery using nanoparticles can minimize the side effects of conventional
pharmaceutical agents and enhance their efficacy. However, translating nanoparticle-based …

Corona composition can affect the mechanisms cells use to internalize nanoparticles

V Francia, K Yang, S Deville, C Reker-Smit, I Nelissen… - ACS …, 2019 - ACS Publications
Nanosized objects, such as nanoparticles and other drug carriers used in nanomedicine,
once in contact with biological environments are modified by adsorption of biomolecules on …

A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles

TB Gandek, L van der Koog… - Advanced healthcare …, 2023 - Wiley Online Library
A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

Possibility of exosome-based therapeutics and challenges in production of exosomes eligible for therapeutic application

T Yamashita, Y Takahashi, Y Takakura - … and Pharmaceutical Bulletin, 2018 - jstage.jst.go.jp
Exosomes are cell-derived vesicles with a diameter 30–120 nm. Exosomes contain
endogenous proteins and nucleic acids; delivery of these molecules to exosome-recipient …

The interaction between nanoparticles-protein corona complex and cells and its toxic effect on cells

N Liu, M Tang, J Ding - Chemosphere, 2020 - Elsevier
Once nanoparticles (NPs) contact with the biological fluids, the proteins immediately adsorb
onto their surface, forming a layer called protein corona (PC), which bestows the biological …

Protein corona, influence on drug delivery system and its improvement strategy: A review

F Guo, S Luo, L Wang, M Wang, F Wu, Y Wang… - International Journal of …, 2024 - Elsevier
Nano drug delivery systems offer several benefits, including enhancing drug solubility,
regulating drug release, prolonging drug circulation time, and minimized toxicity and side …

[HTML][HTML] Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

V Francia, D Montizaan… - Beilstein journal of …, 2020 - beilstein-journals.org
Nano-sized materials have great potential as drug carriers for nanomedicine applications.
Thanks to their size, they can exploit the cellular machinery to enter cells and be trafficked …

Cancer‐targeted nanomedicine: overcoming the barrier of the protein corona

AK Barui, JY Oh, B Jana, C Kim… - Advanced therapeutics, 2020 - Wiley Online Library
Nanomedicines exploit the unusual physicochemical and biological properties of
nanoparticles, including their nanoscopic size, high surface‐area‐to‐volume ratio, easy …