Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Mitochondrial function declines during ageing owing to the accumulation of deleterious
mitochondrial genomes and damage resulting from the localized generation of reactive …

The mitochondrial network is not only required for the production of energy, essential
cofactors and amino acids, but also serves as a signaling hub for innate immune and …

Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and
cell metabolism. Mitochondria contain their own circular genome encoding selected …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

The accumulation of deleterious mitochondrial DNA (∆ mtDNA) causes inherited
mitochondrial diseases and ageing-associated decline in mitochondrial functions such as …