The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

The repeated use of drugs that directly or indirectly stimulate dopamine transmission carry
addiction liability and produce enduring pathological changes in the brain circuitry that …

Potassium fluoride (KF) is an ideal reagent for fluorination because it is safe, easy to handle
and low-cost. However, poor solubility in organic solvents coupled with limited strategies to …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms
including tremor and bradykinesia. The primary pathophysiology underlying PD is the …

The regio‐and enantio‐selective, intermolecular vicinal fluoroamination of α‐trifluoromethyl
styrenes has been achieved by enantioselective II/IIII catalysis. Leveraging C2‐symmetric …

Phase-transfer catalysis (PTC) is one of the most powerful catalytic manifolds for asymmetric
synthesis. Chiral cationic or anionic PTC strategies have enabled a variety of …

Glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors
mediate most of the excitatory neurotransmission in the mammalian central nervous system …

Glutamatergic transmission is widely implicated in neuropsychiatric disorders, and the
discovery that ketamine elicits rapid-acting antidepressant effects by modulating α-amino-3 …

Ampakines are drugs structurally derived from aniracetam that potentiate currents mediated
by AMPA type glutamate receptors. These drugs slow deactivation and attenuate …