Machine learning and analytical methods for single-molecule conductance measurements

Y Komoto, J Ryu, M Taniguchi - Chemical Communications, 2023 - pubs.rsc.org
Single-molecule measurements of single-molecule conductance between metal nanogap
electrodes have been actively investigated for molecular electronics, biomolecular analysis …

Nanopore-based sensors for DNA sequencing: a review

J Wei, H Hong, X Wang, X Lei, M Ye, Z Liu - Nanoscale, 2024 - pubs.rsc.org
Nanopore sensors, owing to their distinctive structural properties, can be used to detect
biomolecular translocation events. These sensors operate by monitoring variations in …

Quantitative Microscopic Observation of Base–Ligand Interactions via Hydrogen Bonds by Single-Molecule Counting

Y Takashima, Y Komoto, T Ohshiro… - Journal of the …, 2023 - ACS Publications
Chemical properties have been based on statistical averages since the introduction of
Avogadro's number. The lack of suitable methods for counting identified single molecules …

Sub-5 nm nanogap electrodes towards single-molecular biosensing

Q He, L Tang - Biosensors and Bioelectronics, 2022 - Elsevier
Nanogap electrodes (NGEs) with sub-5 nm gap has been widely used in single-molecule
sensing and sequencing, with the characteristics of label-free, high sensitivity, rapid …

Coordination of RNA modifications in the brain and beyond

AY Chen, MC Owens, KF Liu - Molecular Psychiatry, 2023 - nature.com
Gene expression regulation is a critical process throughout the body, especially in the
nervous system. One mechanism by which biological systems regulate gene expression is …

[HTML][HTML] Nanofluidic Manipulation of Single Nanometric Objects: Current Progress, Challenges, and Future Opportunities

N Chantipmanee, Y Xu - Engineering, 2024 - Elsevier
The manipulation of nanometric objects, encompassing both non-biological and biological
objects, offers a transformative avenue for breakthroughs in diverse fields, such as …

RNA modification in inflammatory bowel diseases

M Nakayama, Y Ozato, Y Tsuji, Y Arao, C Otsuka… - Biomedicines, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by
damage to the intestinal mucosa, which is caused by a combination of factors. These include …

A review of advances in analytical strategies for RNA methylation

H Sun, F Yin, Z Zou, Y Gu, C Guo - Analytica Chimica Acta, 2024 - Elsevier
Abstract N6-methyladenosine (m 6 A) is the most prevalent RNA methylation modification,
and its dysregulation causes aberrant transcription and translation, which plays critical roles …

Direct biomolecule discrimination in mixed samples using nanogap-based single-molecule electrical measurement

J Ryu, Y Komoto, T Ohshiro, M Taniguchi - Scientific Reports, 2023 - nature.com
In single-molecule measurements, metal nanogap electrodes directly measure the current of
a single molecule. This technique has been actively investigated as a new detection method …

Recent advance in optical single-molecule detection of methylation modification and methyl-modifying enzymes

Y Han, D Yang, S Jiang, S Zhao, F Ma… - TrAC Trends in Analytical …, 2024 - Elsevier
As the predominant epigenetic markers, methyl-modifying enzymes-catalyzed methylation
modification widely participates in the regulation of cellular functions, and the dysregulation …