Breast cancer is a heterogeneous disease and differs greatly among different patients
(intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity) …

Objective To study the pathophysiology of endometriosis. Design Overview of observations
on endometriosis. Setting Not applicable. Patient (s) None. Interventions (s) None. Main …

Traditionally, intertumour heterogeneity in breast cancer has been documented in terms of
different histological subtypes, treatment sensitivity profiles, and clinical outcomes among …

Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features.
The incidence rate escalates. A high number of clones harboring various mutations …

Breast cancer is a heterogeneous disease, comprising multiple entities associated with
distinctive histological and biological features, clinical presentations and behaviours and …

Little is known of the genetic architecture of cancer at the subclonal and single-cell level or
in the cells responsible for cancer clone maintenance and propagation. Here we have …

Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like
phenotype. It has been suggested that this results from an origin in basal breast epithelial …

In recent years it has become clear that cancer cells within a single tumor can display
striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic …

Despite the success of targeted therapies in the treatment of cancer, the development of
resistance limits the ability to translate this method into a curative treatment. The …

Most advanced solid tumors remain incurable, with resistance to chemotherapeutics and
targeted therapies a common cause of poor clinical outcome. Intratumor heterogeneity may …