[HTML][HTML] VEGF/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment

Y Zhao, S Guo, J Deng, J Shen, F Du… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is the leading cause of death by cancer worldwide.
Despite developments in therapeutic approaches for the past few decades, the 5-year …

The role of neutrophil extracellular traps in cancer progression and metastasis

ML De Meo, JD Spicer - Seminars in immunology, 2021 - Elsevier
Neutrophil extracellular traps (NET) are the extracellular release of decondensed chromatin
and granules known for their role in host defense against foreign pathogens. However, a …

G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors

K He, X Liu, RD Hoffman, RZ Shi, GY Lv… - FEBS open …, 2022 - Wiley Online Library
There are two types of abnormal hematopoiesis in solid tumor occurrence and treatment:
pathological hematopoiesis, and myelosuppression induced by radiotherapy and …

Tumor-derived nanoseeds condition the soil for metastatic organotropism

M Hu, CM Kenific, N Boudreau, D Lyden - Seminars in Cancer Biology, 2023 - Elsevier
Primary tumors secrete a variety of factors to turn distant microenvironments into favorable
and fertile 'soil'for subsequent metastases. Among these 'seeding'factors that initiate pre …

Exosomes in Cancer Progression and Therapy Resistance: Molecular Insights and Therapeutic Opportunities

M Wandrey, J Jablonska, RH Stauber, D Gül - Life, 2023 - mdpi.com
The development of therapy resistance still represents a major hurdle in treating cancers,
leading to impaired treatment success and increased patient morbidity. The establishment of …

Adipose tissue-derived extracellular vesicles and the tumor microenvironment: revisiting the hallmarks of cancer

JA Moraes, C Encarnação, VA Franco… - Cancers, 2021 - mdpi.com
Simple Summary Increased body fat is associated with an increased risk of 13 different
cancer types. Recent findings have demonstrated a close relationship between extracellular …

Neutrophils at the crossroads: unraveling the multifaceted role in the tumor microenvironment

D Awasthi, A Sarode - International Journal of Molecular Sciences, 2024 - mdpi.com
Over the past decade, research has prominently established neutrophils as key contributors
to the intricate landscape of tumor immune biology. As polymorphonuclear granulocytes …

Targeting NADPH oxidase and integrin α5β1 to inhibit neutrophil extracellular traps-mediated metastasis in colorectal cancer

W Zhu, S Yang, D Meng, Q Wang, J Ji - International Journal of Molecular …, 2023 - mdpi.com
Metastasis leads to a high mortality rate in colorectal cancer (CRC). Increased neutrophil
extracellular traps (NETs) formation is one of the main causes of metastasis. However, the …

Immune checkpoint inhibitors, small-molecule immunotherapies and the emerging role of neutrophil extracellular traps in therapeutic strategies for head and neck …

CH O'Meara, Z Jafri, LM Khachigian - International Journal of Molecular …, 2023 - mdpi.com
Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of many cancer
types, including head and neck cancers (HNC). When checkpoint and partner proteins bind …

Effect of tertiary lymphoid structures on prognosis of patients with hepatocellular carcinoma and preliminary exploration of its formation mechanism

J Li, Y Nie, W Jia, W Wu, W Song, Y Li - Cancers, 2022 - mdpi.com
Simple Summary At present, research on tertiary lymphoid structures (TLSs) in
hepatocellular carcinoma (HCC) has been limited to the prognostic impact. Our manuscript …