Fox transcription factors: from development to disease
ML Golson, KH Kaestner - Development, 2016 - journals.biologists.com
Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …
from yeast to humans. They regulate diverse biological processes both during development …
Pancreas organogenesis: from bud to plexus to gland
FC Pan, C Wright - Developmental dynamics, 2011 - Wiley Online Library
Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …
events and transcriptional networks that guide a step‐wise process of organ development …
[HTML][HTML] Enhancer reprogramming promotes pancreatic cancer metastasis
JS Roe, CI Hwang, TDD Somerville, JP Milazzo… - Cell, 2017 - cell.com
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies,
owing in part to its propensity for metastasis. Here, we used an organoid culture system to …
owing in part to its propensity for metastasis. Here, we used an organoid culture system to …
[HTML][HTML] Deciphering early human pancreas development at the single-cell level
Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases
and 57,574 controls of European ancestry. We identified 49 distinct association signals at …
and 57,574 controls of European ancestry. We identified 49 distinct association signals at …
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors
Poorly differentiated neuroendocrine carcinomas (NECs) of the pancreas are rare malignant
neoplasms with a poor prognosis. The aim of this study was to determine the …
neoplasms with a poor prognosis. The aim of this study was to determine the …
GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer
P Martinelli, E Carrillo-de Santa Pau, T Cox, B Sainz… - Gut, 2017 - gut.bmj.com
Background and aims The role of GATA factors in cancer has gained increasing attention
recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is …
recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is …
Genomic views of distant-acting enhancers
In contrast to protein-coding sequences, the significance of variation in non-coding DNA in
human disease has been minimally explored. A great number of recent genome-wide …
human disease has been minimally explored. A great number of recent genome-wide …
3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk
Summary Three-dimensional (3D) chromatin organization maps help dissect cell-type-
specific gene regulatory programs. Furthermore, 3D chromatin maps contribute to …
specific gene regulatory programs. Furthermore, 3D chromatin maps contribute to …
[HTML][HTML] Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer
Z Li, G Tuteja, J Schug, KH Kaestner - Cell, 2012 - cell.com
Hepatocellular carcinoma (HCC) is sexually dimorphic in both rodents and humans, with
significantly higher incidence in males, an effect that is dependent on sex hormones. The …
significantly higher incidence in males, an effect that is dependent on sex hormones. The …