Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

The molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to
facilitate the function of numerous oncoproteins, and it can be argued that cancer cells …

Cells are repeatedly exposed to environmental or endogenous stresses that can alter
normal cell behavior and increase cell vulnerability. In order to ensure tissue integrity and …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

We present a comprehensive analysis of the human methyltransferasome. Primary
sequences, predicted secondary structures, and solved crystal structures of known …

Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …

Within the vast landscape of histone modifications lysine methylation has gained increasing
attention because of its profound regulatory potential. The methylation of lysine residues on …

SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-
DEAF1) domain-containing proteins (SMYD) have been found to methylate a variety of …

Epigenetic control mechanisms determine active and silenced regions of the genome. It is
known that the Polycomb Repressive Complex 2 (PRC2) and the Trithorax group/Mixed …