Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …

Numerous strategies for linking desired chemical probes with target peptides and proteins
have been developed and applied in the field of biological chemistry. Approaches for site …

The demand for creation of protein diversity and regulation of protein function through native
protein modification and post-translational modification has ignited the development of …

Advances in the site-specific chemical modification of proteins, also referred to as protein
bioconjugation, have proved instrumental in revolutionary approaches to designing new …

Widely used reagents in the peptide functionalization toolbox, Michael acceptors and N‐
hydroxysuccinimide (NHS) activated esters, are combined in NHS‐activated acrylamides for …

Phage display, an ingenious invention for evaluating peptide libraries, has been limited to
natural peptides that are ribosomally assembled with proteinogenic amino acids. Recently …

N‐terminal modifications of proteins have garnered the attention of chemical biologists
because of their critical roles in numerous cellular processes, including protein …

The demand for new biomass‐derived fine and commodity chemicals propels the discovery
of new methodologies and synthons. Whereas furfural and 5‐hydroxymethylfurfural are …

This work reports a novel chlorooxime mediated modification of native peptides and proteins
under physiologic conditions. This method features fast reaction kinetics (apparent k2 …

Site-selective, dual-conjugation approaches for the incorporation of distinct payloads are
key for the development of molecularly targeted biomolecules, such as antibody conjugates …