Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention
A Baragaño Raneros, B Suarez Álvarez… - …, 2014 - Taylor & Francis
Natural Killer Group 2 member D (NKG2D) activating receptor, present on the surface of
various immune cells, plays an important role in activating the anticancer immune response …
various immune cells, plays an important role in activating the anticancer immune response …
A potential mechanism of tumor immune escape: Regulation and application of soluble natural killer group 2 member D ligands
S Huang, Z Qin, F Wang, Y Kang… - Oncology …, 2024 - spandidos-publications.com
The immune system is integral to the surveillance and eradication of tumor cells. Interactions
between the natural killer group 2 member D (NKG2D) receptor and its ligands (NKG2DLs) …
between the natural killer group 2 member D (NKG2D) receptor and its ligands (NKG2DLs) …
Immune evasion by proteolytic shedding of natural killer group 2, member D ligands in Helicobacter pylori infection
M Anthofer, M Windisch, R Haller, S Ehmann… - Frontiers in …, 2024 - frontiersin.org
Background Helicobacter pylori (H. pylori) uses various strategies that attenuate mucosal
immunity to ensure its persistence in the stomach. We recently found evidence that H. pylori …
immunity to ensure its persistence in the stomach. We recently found evidence that H. pylori …
Vorinostat upregulates MICA via the PI3K/Akt pathway to enhance the ability of natural killer cells to kill tumor cells
C Xia, Z He, Y Cai, S Liang - European Journal of Pharmacology, 2020 - Elsevier
Vorinostat has good therapeutic efficacy against primary cutaneous T-cell lymphoma in the
refractory stage. However, the molecular mechanism by which it inhibits solid tumors has not …
refractory stage. However, the molecular mechanism by which it inhibits solid tumors has not …
Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis
PJ Amin, BS Shankar - Life sciences, 2015 - Elsevier
Aims The goal of this study is to investigate the tumor cytotoxic effects of sulforaphane (SFN)
and ionizing radiation (IR) as well as their ability to up-regulate natural killer group 2 …
and ionizing radiation (IR) as well as their ability to up-regulate natural killer group 2 …
Molecular and genomic approach for understanding the gene-environment interaction between Nrf2 deficiency and carcinogenic nickel-induced DNA damage
HL Kim, YR Seo - Oncology reports, 2012 - spandidos-publications.com
Nickel (Ⅱ) is a toxic and carcinogenic metal which induces a redox imbalance following
oxidative stress. Nuclear factor erythroid-2 related factor 2 (Nrf2) is a redox factor that …
oxidative stress. Nuclear factor erythroid-2 related factor 2 (Nrf2) is a redox factor that …
Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications
MI Jimenez-Perez, LF Jave-Suarez… - BMC immunology, 2012 - Springer
Background Cervical cancer represents the third most commonly diagnosed cancer and the
fourth leading cause of cancer-related deaths in women worldwide. Natural killer (NK) cells …
fourth leading cause of cancer-related deaths in women worldwide. Natural killer (NK) cells …
NKG2D Ligand–Targeted Bispecific T-Cell Engagers Lead to Robust Antitumor Activity against Diverse Human Tumors
C Godbersen, TA Coupet, AM Huehls, T Zhang… - Molecular cancer …, 2017 - AACR
Two new bispecific T-cell engaging (BiTE) molecules with specificity for NKG2D ligands
were developed and functionally characterized. One, huNKG2D-OKT3, was derived from the …
were developed and functionally characterized. One, huNKG2D-OKT3, was derived from the …
Bispecific antibodies progression in malignant melanoma
J Tang, Y Gong, X Ma - Frontiers in Pharmacology, 2022 - frontiersin.org
The discovery of oncogenes and immune checkpoints has revolutionized the treatment of
melanoma in the past 10 years. However, the current PD-L1 checkpoints lack specificity for …
melanoma in the past 10 years. However, the current PD-L1 checkpoints lack specificity for …
Comprehensive profiling of N-linked glycosylation sites in HeLa cells using hydrazide enrichment
H Malerod, RLJ Graham, MJ Sweredoski… - Journal of Proteome …, 2013 - ACS Publications
The adenocarcinoma cell line HeLa serves as a model system for cancer research in
general and cervical cancer in particular. In this study, hydrazide enrichment in combination …
general and cervical cancer in particular. In this study, hydrazide enrichment in combination …