Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease, but many rheumatologists are not well acquainted with its management. The …

(1) Background: Familial Mediterranean Fever (FMF) is the prototypal autoinflammatory
disease, characterized by recurrent bursts of neutrophilic inflammation.(2) Methods: In this …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease (AID) affecting mainly the ethnic groups originating from Mediterranean basin. The …

The inflammasome is a cytoplasmic multiprotein complex that promotes proinflammatory
cytokine maturation in response to host-and pathogen-derived signals. Missense mutations …

Abstract Background Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory
syndrome characterized by recurrent serositis or arthritis attacks and, in some patients …

Abstract Aim Familial Mediterranean Fever (FMF) is the most common recurrent
autoinflammatory fever syndrome. Still, many issues—eg: colchicine dosage adjustment …

Monogenic autoinflammatory diseases are rare conditions caused by genetic abnormalities
affecting the innate immunity. Previous therapeutic strategies had been mainly based on …

Objective Inflammatory attacks of familial Mediterranean fever (FMF) are characterised by
circulation and influx of high number of polymorphonuclear neutrophils (PMN) in the affected …