Aging of the heart is associated with a blunted response to sympathetic stimulation, reduced
contractility, and increased propensity for arrhythmias, with the risk of sudden cardiac death …

Depressed sarcoplasmic reticulum (SR) calcium cycling, reflecting impaired SR Ca-transport
and Ca-release, is a key and universal characteristic of human and experimental heart …

Background Recognition of cardiomyopathy in sepsis can be challenging due to the
limitations of conventional measures such as ejection fraction (EF) and fractional shortening …

Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It
is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts …

Heart failure and aging of the heart show many similarities regarding hemodynamic and
biochemical parameters. There is evidence that heart failure in experimental animals and …

Ischemia/reperfusion injury is associated with contractile dysfunction and increased
cardiomyocyte death. Overexpression of the hematopoietic lineage substrate-1-associated …

Aims Impaired sarcoplasmic reticulum (SR) Ca2+ cycling and depressed contractility, a
hallmark of human and experimental heart failure, has been partially attributed to increased …

Phosphoproteomic studies have shown that about one third of all cardiac proteins are
reversibly phosphorylated, affecting virtually every cellular signaling pathway. The …

The downregulation of β-adrenergic receptors (β-AR) and decreased cAMP-dependent
protein kinase activity in failing hearts results in decreased phosphorylation and inactivation …

We review the recent development of novel biochemical and spectroscopic methods to
determine the site-specific phosphorylation, expression, mutation, and structural dynamics of …