Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a
common autosomal dominant syndrome characterized by early age at onset, neoplastic …

Colorectal cancers among patients with a familial risk of this disorder account for
approximately one of five cases of this disease. Many cases can be prevented by the …

We describe a new method for relative quantification of 40 different DNA sequences in an
easy to perform reaction requiring only 20 ng of human DNA. Applications shown of this …

Familial colorectal cancer (CRC) is a major public health problem by virtue of its relatively
high frequency. Some 15-20% of all CRCs are familial. Among these, familial adenomatous …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

PURPOSE: Cancer morbidity and mortality can be dramatically reduced by colonoscopic
screening of individuals with the hereditary nonpolyposis colorectal cancer (HNPCC) …

Hereditary ovarian cancer accounts for at least 5% of the estimated 22,000 new cases of this
disease during 2009. During this same time, over 15,000 will die from malignancy ascribed …

Loss-of-function defects in DNA mismatch repair (MMR), which manifest as high levels of
microsatellite instability (MSI), occur in approximately 15% of all colorectal carcinomas …