A genotypic test for HIV-1 tropism combining Sanger sequencing with ultradeep sequencing predicts virologic response in treatment-experienced patients
RM Kagan, EP Johnson, M Siaw, P Biswas… - 2012 - journals.plos.org
A tropism test is required prior to initiation of CCR5 antagonist therapy in HIV-1 infected
individuals, as these agents are not effective in patients harboring CXCR4 (X4) coreceptor …
individuals, as these agents are not effective in patients harboring CXCR4 (X4) coreceptor …
HIV-1 tropism determination using a phenotypic Env recombinant viral assay highlights overestimation of CXCR4-usage by genotypic prediction algorithms for …
M Mulinge, M Lemaire, JY Servais, A Rybicki, D Struck… - PloS one, 2013 - journals.plos.org
Background Human Immunodeficiency virus type-1 (HIV) entry into target cells involves
binding of the viral envelope (Env) to CD4 and a coreceptor, mainly CCR5 or CXCR4. The …
binding of the viral envelope (Env) to CD4 and a coreceptor, mainly CCR5 or CXCR4. The …
HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug
SM Schader, SP Colby-Germinario… - Antimicrobial agents …, 2012 - Am Soc Microbiol
ABSTRACT BMS-599793 is a small molecule entry inhibitor that binds to human
immunodeficiency virus type 1 (HIV-1) gp120, resulting in the inhibition of CD4-dependent …
immunodeficiency virus type 1 (HIV-1) gp120, resulting in the inhibition of CD4-dependent …
Deep sequencing increases hepatitis C virus phylogenetic cluster detection compared to Sanger sequencing
V Montoya, A Olmstead, P Tang, D Cook… - Infection, Genetics and …, 2016 - Elsevier
Effective surveillance and treatment strategies are required to control the hepatitis C virus
(HCV) epidemic. Phylogenetic analyses are powerful tools for reconstructing the …
(HCV) epidemic. Phylogenetic analyses are powerful tools for reconstructing the …
Forensic application of phylogenetic analyses–exploration of suspected HIV-1 transmission case
M Siljic, D Salemovic, V Cirkovic… - Forensic Science …, 2017 - Elsevier
Transmission of human immunodeficiency virus (HIV) between individuals may have
important legal implications and therefore may come to require forensic investigation based …
important legal implications and therefore may come to require forensic investigation based …
Host genetic factors associated with symptomatic primary HIV infection and disease progression among Argentinean seroconverters
RS Coloccini, D Dilernia, Y Ghiglione, G Turk, N Laufer… - PloS one, 2014 - journals.plos.org
Background Variants in HIV-coreceptor CC chemokine receptor type 5 (CCR5) and Human
leukocyte antigen (HLA) genes are the most important host genetic factors associated with …
leukocyte antigen (HLA) genes are the most important host genetic factors associated with …
Prevalence of R5 and X4 HIV variants in antiretroviral treatment experienced patients with virologic failure
P Ferrer, M Tello, L Montecinos, R Tordecilla… - Journal of Clinical …, 2014 - Elsevier
Background Antiretroviral therapy (ART) inhibits virus replication. Nevertheless, ART has the
disadvantage of generate selective resistance and adverse events. Coreceptor antagonists …
disadvantage of generate selective resistance and adverse events. Coreceptor antagonists …
Correlation of the virological response to short-term maraviroc monotherapy with standard and deep-sequencing-based genotypic tropism prediction methods
A Gonzalez-Serna, RA McGovern… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Genotypic tropism testing methods are emerging as the first step before prescription of the
CCR5 antagonist maraviroc (MVC) to HIV-infected patients in Europe. Studies validating …
CCR5 antagonist maraviroc (MVC) to HIV-infected patients in Europe. Studies validating …
Comparison of genotypic and phenotypic HIV type 1 tropism assay: results from the screening samples of cenicriviroc study 202, a randomized phase II trial in …
RM Kagan, EP Johnson, MF Siaw… - AIDS research and …, 2014 - liebertpub.com
Cenicriviroc is a once-daily oral CCR5/CCR2 antagonist in development for treatment of HIV
infection. CVC Study 202 (652-2-202; NCT01338883) excluded treatment-naive subjects …
infection. CVC Study 202 (652-2-202; NCT01338883) excluded treatment-naive subjects …
The genotypic false positive rate determined by V3 population sequencing can predict the burden of HIV-1 CXCR4-using species detected by pyrosequencing
V Svicher, V Cento, G Rozera, I Abbate, MM Santoro… - PLoS …, 2013 - journals.plos.org
Objective The false-positive rate (FPR) is a percentage-score provided by Geno2Pheno-
algorithm indicating the likelihood that a V3-sequence is falsely predicted as CXCR4-using …
algorithm indicating the likelihood that a V3-sequence is falsely predicted as CXCR4-using …