Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

Age-related macular degeneration (AMD) remains a major cause of blindness, with
dysfunction and loss of retinal pigment epithelium (RPE) central to disease progression. We …

The immunogenicity of transplanted allogeneic cells and tissues is a major hurdle to the
advancement of cell therapies. Here we show that the overexpression of eight …

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

Differentiation methods for human induced pluripotent stem cells (hiPSCs) typically yield
progeny from multiple tissue lineages, limiting their use for drug testing and autologous cell …

Human pluripotent stem cells have the potential to provide comprehensive model systems
for the earliest stages of human ontogenesis. To serve in this capacity, these cells must …

Advanced macular degeneration is an important cause of vision loss in the United States
with over 2 million people affected by the disease. Despite substantial progress in the …

Inherited retinal degenerative diseases, a genetically and phenotypically heterogeneous
group of disorders, affect the function of photoreceptor cells and are among the leading …

Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …