Toluene toxicity in the brain: from cellular targets to molecular mechanisms

AA Shaw, JD Steketee, AN Bukiya… - Annual Review of …, 2025 - annualreviews.org
Toluene intoxication constitutes a persistent public health problem worldwide. While most
organs can be damaged, the brain is a primary target whether exposure is accidental …

Abuse-like toluene exposure during early adolescence alters subsequent ethanol and cocaine behavioral effects and brain monoamines in male mice

CJ Davidson, JH Hannigan, SA Perrine… - Neurotoxicology and …, 2024 - Elsevier
Currently, there is a gap in understanding the neurobiological impact early adolescent
toluene exposure has on subsequent actions of other drugs. Adolescent (PND 28–32) male …

A brief exposure to toluene vapor alters the intrinsic excitability of D2 medium spiny neurons in the rat ventral striatum

M Okas, A Kastner, D Gioia, JJ Woodward - Frontiers in Neuroscience, 2023 - frontiersin.org
Although volatile organic solvents such as toluene are used for commercial and industrial
uses, they are often voluntarily inhaled for their intoxicating and euphoric effects. Research …

[HTML][HTML] Toluene is a cerebral artery constrictor acting via BK channels

AA Shaw, JD Steketee, AN Bukiya, AM Dopico - Neuropharmacology, 2025 - Elsevier
Acute intoxication by toluene usually follows intentional inhalation to achieve a “high”, which
may lead to repeated use due to toluene's reinforcing properties. In both acute and chronic …

[HTML][HTML] Toluene alters the intrinsic excitability and excitatory synaptic transmission of basolateral amygdala neurons

K Braunscheidel, M Okas, JJ Woodward - Frontiers in Neuroscience, 2024 - frontiersin.org
Introduction Inhalant abuse is an important health issue especially among children and
adolescents who often encounter these agents in the home. Research into the …

Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior

JLB Asis, AC Carampel, JNB Bacar, JC Munar… - …, 2024 - Springer
Objective We assessed the behavioral effects during prolonged abstinence following
repeated toluene inhalation in adolescent male and female rats. Methods We repeatedly …

Repeated toluene and cyclohexane inhalation produces differential effects on HPA and HPT axes in adolescent male rats

P Soberanes-Chávez, P de Gortari, C García-Luna… - NeuroToxicology, 2023 - Elsevier
Misused volatile solvents typically contain toluene (TOL) as the main psychoactive
ingredient. Cyclohexane (CHX) can also be present and is considered a safer alternative …

The new trend of some inhalant use: Risks and warnings of false harmlessness

J Cárdenas-Quesada, C Pérez-Mañá… - Medicina …, 2023 - pubmed.ncbi.nlm.nih.gov
The new trend of some inhalant use: Risks and warnings of false harmlessness The new trend of
some inhalant use: Risks and warnings of false harmlessness Med Clin (Barc). 2023 Dec …

[PDF][PDF] Risk Factors and Consequences of Drug Abuse Among Undergraduate Students

IS Oluwole, AG ISHOLA, IO OJO, O BABARIMISA - ijmnhs.com
Drug abuse among undergraduate students is a pressing concern with profound
implications for academic performance, physical health, and mental well-being. This study …

[引用][C] La nueva moda de consumo de algunos inhalantes: riesgos y alerta por la falsa inocuidad

JC Quesada, CP Mañá, EP Fontanet… - Medicina …, 2023 - dialnet.unirioja.es