Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease, leads to
blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction …

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently
affecting over 5 million Americans with projections expected to rise as the population ages …

Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …

Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …

Common genetic variants in more than forty loci modulate risk for Alzheimer's disease (AD).
AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that …

The strongest genetic risk factor for late‐onset Alzheimer's disease (AD) is allelic variation of
the APOE gene, with the following risk structure: ε4> ε3> ε2. The biochemical basis for this …