Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

Keratins make up the largest subgroup of intermediate filament proteins and represent the
most abundant proteins in epithelial cells. They exist as highly dynamic networks of …

It took more than 100 years before it was established that the proteins that form intermediate
filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

Intermediate filaments, actin-containing microfilaments and microtubules are the three main
cytoskeletal systems of vertebrate and many invertebrate cells. Although these systems are …

Nestin is an intermediate filament protein expressed in dividing cells during the early stages
of development in the CNS, PNS and in myogenic and other tissues. Upon differentiation …

The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that
are responsible to protect epithelial cells against mechanical stress and to act as signaling …

Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …

Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive lipid that is present in
high density lipoproteins (HDL) particles and found at increased levels in blood and …

Recent evidence showing that intermediate filaments (IFs) are dynamic, motile elements of
the cytoskeletal repertoire of vertebrate cells has overturned the long-standing view that they …