The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Ca2+ mobilization from intracellular stores represents an important cell signalling process
that is regulated, in mammalian cells, by inositol-1, 4, 5-trisphosphate (InsP3), cyclic ADP …

Since the beginning of the last century, seminal discoveries have identified pyridine
nucleotides as the major redox carriers in all organisms. Recent research has unravelled an …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-
mobilizing messenger that is highly unusual in activating calcium channels located on acidic …

Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …

Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …

Research into the biological role of the Ca2+-releasing second messenger NAADP
(nicotinic acid adenine dinucleotide phosphate) has been hampered by a lack of chemical …

Vascular endothelial growth factor (VEGF) and its receptors VEGFR1/VEGFR2 play major
roles in controlling angiogenesis, including vascularization of solid tumors. Here we …