Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Doxorubicin is one of the most important anti-cancer chemotherapeutic drugs, being widely
used for the treatment of solid tumors and acute leukemias. The action of doxorubicin and …

The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9
system for genome editing has greatly expanded the toolbox for mammalian genetics …

DNA-damaging agents have a long history of use in cancer chemotherapy. The full extent of
their cellular mechanisms, which is essential to balance efficacy and toxicity, is often …

Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements.
They are essential during transcription and replication, and topoisomerase inhibitors are …

The goal of this study is to give a brief background on the literature supporting the
PharmGKB pathway about doxorubicin action, and provides a summary of this active area of …

Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …

Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy
protocols. Severe side effects such as cardiotoxicity, however, limit Dox application …

Tumours with specific DNA repair defects can be completely dependent on back-up DNA
repair pathways for their survival. This dependence can be exploited therapeutically to …

Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …