Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess
kidney disease risk in African Americans; however, the molecular pathways of APOL1 …

Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …

Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the
excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have …

Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …

People of recent sub-Saharan African ancestry develop kidney failure much more frequently
than other groups. A large fraction of this disparity is due to two coding sequence variants in …

Genetic variants in the APOL1 gene, found only in individuals of recent African ancestry,
greatly increase risk of multiple types of kidney disease. These APOL1 kidney risk alleles …

Disturbed renal lipid metabolism, especially cholesterol dysregulation plays a crucial role in
the pathogenesis of chronic kidney disease (CKD). We recently reported that angiotensin …

Autophagy is a ubiquitous intracellular cytoprotective quality control program that maintains
cellular homeostasis by recycling superfluous cytoplasmic components (lipid droplets …