Numerous animal and human studies have assessed the relationship between polyphenols
and outcomes related to depression. However, no comprehensive synthesis of the main …

Mitochondria, the 'powerhouse'of eukaryotic cells, play a key role in cellular homeostasis.
However, defective mitochondria increase mitochondrial ROS (mtROS) production and cell …

Diabetes increases the likelihood of developing depression and vice versa. Research on
this bidirectional association has somewhat managed to delineate the interplay among …

Depression has huge social risks of high incidence, disability, and suicide. Its prevalence
and harm in people with hyperglycemia are 2–3 times higher than in normal people …

Neuropsychiatric disorders are anticipated to be a leading health concern in the near future,
emphasizing an outstanding need for the development of new effective therapeutics to treat …

Mental health is a global public concern that contributes raising disability and premature
death. Anxiety undertakes around 3.6% of the global population, while psychological stress …

Social isolation (SI) is a major risk factor for mood disorders in adolescents. The nucleus
accumbens (NAc) is an important reward center implicated in psychiatric disorders …

Impaired wound healing is one of a variety of severe diabetic complications and involves
many factors, including consistent oxidative stress, prolonged inflammation, impaired …

Bipolar-disorder's pathophysiology and the mechanism by which medications exert their
beneficial effect is yet unknown, but others' and our data implicate patients' brain …

Innate immunity activation in the central nervous system (CNS) is known to contribute to the
development of depression through NOD-like receptors containing pyrin domain 3 (NLRP3) …