Cell-penetrating peptides: design, synthesis, and applications
DM Copolovici, K Langel, E Eriste, U Langel - ACS nano, 2014 - ACS Publications
The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …
[HTML][HTML] Role of PACAP in migraine: An alternative to CGRP?
Migraine is a widespread and debilitating neurological condition affecting more than a
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …
Recent uses of lipid nanoparticles, cell-penetrating and bioactive peptides for the development of brain-targeted nanomedicines against neurodegenerative disorders
Y Wu, A Angelova - Nanomaterials, 2023 - mdpi.com
The lack of effective treatments for neurodegenerative diseases (NDs) is an important
current concern. Lipid nanoparticles can deliver innovative combinations of active molecules …
current concern. Lipid nanoparticles can deliver innovative combinations of active molecules …
PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma
JA Waschek, SM Baca, S Akerman - The journal of headache and pain, 2018 - Springer
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary
adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large …
adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large …
Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger–Westphal Nucleus in the Rotenone model …
M Fehér, Z Márton, Á Szabó, J Kocsa… - International Journal of …, 2023 - mdpi.com
Numerous in vitro and in vivo models of Parkinson's disease (PD) demonstrate that pituitary
adenylate cyclase-activating polypeptide (PACAP) conveys its strong neuroprotective …
adenylate cyclase-activating polypeptide (PACAP) conveys its strong neuroprotective …
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its …
JM Lugo, C Tafalla, A Oliva, T Pons, B Oliva… - Fish & shellfish …, 2019 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a regulatory neuropeptide that
belongs to the secretin/glucagon superfamily, of which some members have shown …
belongs to the secretin/glucagon superfamily, of which some members have shown …
Review on PACAP-induced transcriptomic and proteomic changes in neuronal development and repair
A Rivnyak, P Kiss, A Tamas, D Balogh… - International journal of …, 2018 - mdpi.com
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with
widespread occurrence and diverse biological effects. Among its several different effects, of …
widespread occurrence and diverse biological effects. Among its several different effects, of …
Female reproductive functions of the neuropeptide PACAP
M Koppan, Z Nagy, I Bosnyak, D Reglodi - Frontiers in Endocrinology, 2022 - frontiersin.org
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide originally
isolated as a hypothalamic peptide. It has a widespread distribution in the body and has a …
isolated as a hypothalamic peptide. It has a widespread distribution in the body and has a …
PACAP27 is protective against tat-induced neurotoxicity
SJ Rozzi, G Borelli, K Ryan, JP Steiner… - Journal of molecular …, 2014 - Springer
Human immunodeficiency virus type-1 (HIV) infection of the central nervous system
promotes neuronal injury and apoptosis that culminate in HIV-associated neurocognitive …
promotes neuronal injury and apoptosis that culminate in HIV-associated neurocognitive …
[HTML][HTML] Secondary conformational conversion is involved in glycosaminoglycans-mediated cellular uptake of the cationic cell-penetrating peptide PACAP
AT Neree, PT Nguyen, D Chatenet, A Fournier… - FEBS letters, 2014 - Elsevier
Glycosaminoglycans (GAGs) contribute to the cellular uptake of cationic cell-penetrating
peptides (CPPs). However, molecular details about the contributions of GAGs in CPP …
peptides (CPPs). However, molecular details about the contributions of GAGs in CPP …