Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …

Highlights•Glycopeptide antibiotics are last-resort antibiotics against drug-resistant
bacteria.•Chemical GPA modifications can be used to overcome bacterial resistance.• …

Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous
structural diversity and a broad range of biological activities useful in the medical and agro …

Engineered biosynthetic assembly lines could revolutionize the sustainable production of
bioactive natural product analogs. Although yeast display is a proven, powerful tool for …

Non-ribosomal peptide synthetases are assembly line biosynthetic pathways that are used
to produce critical therapeutic drugs and are typically arranged as large multi-domain …

In the quest for new bioactive substances, nonribosomal peptide synthetases (NRPS)
provide biodiversity by synthesizing nonproteinaceous peptides with high cellular activity …

Polyketides and nonribosomal peptides are an important class of natural products with
useful bioactivities. These compounds are similarly biosynthesized using enzymes with …

Nonribosomal peptides (NRPs) have gained attention due to their diverse biological
activities and potential applications in medicine and agriculture. The natural diversity of …

Nonribosomal peptide synthetases (NRPSs) biosynthesize nonribosomal peptide (NRP)
natural products, which belong to the most promising resources for drug discovery and …

Cyclic lipopeptides, as a novel and green biosurfactant, has crucial biological functions,
including antiviral, anti-inflammatory, anti-cancer, and environmental healing. However, the …