Photodynamic therapy—current limitations and novel approaches

G Gunaydin, ME Gedik, S Ayan - Frontiers in Chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …

Upconversion-based photodynamic cancer therapy

Y Liu, X Meng, W Bu - Coordination chemistry reviews, 2019 - Elsevier
Photodynamic therapy (PDT) has become widely accepted and utilized for tumor therapy.
Considering the natural shortcomings (eg, lack of an ideal photosensitizer and limited light …

Photodynamic therapy

TJ Dougherty, CJ Gomer, BW Henderson… - Journal of National …, 1998 - academic.oup.com
Photodynamic therapy involves administration of a tumorlocalizing photosensitizing agent,
which may require metabolic synthesis (ie, a prodrug), followed by activation of the agent by …

Photodynamic therapy and immunity: an update

R Falk‐Mahapatra, SO Gollnick - Photochemistry and …, 2020 - Wiley Online Library
Abstract Dr. Thomas Dougherty and his Oncology Foundation of Buffalo were the first to
support my (SOG) research into the effects of photodynamic therapy (PDT) on the host …

Photodynamic therapy and anti-tumour immunity

AP Castano, P Mroz, MR Hamblin - Nature Reviews Cancer, 2006 - nature.com
Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in
combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant …

Basic principles of photodynamic therapy

IJ Macdonald, TJ Dougherty - Journal of porphyrins and …, 2001 - World Scientific
The therapeutic use of light, as we know it, begins in 1900 when Raab reported that the
combination of acridine orange and light could destroy living organisms (paramecium)[1]. In …

Mechanisms in photodynamic therapy: part two—cellular signaling, cell metabolism and modes of cell death

AP Castano, TN Demidova, MR Hamblin - … and photodynamic therapy, 2005 - Elsevier
Photodynamic therapy (PDT) has been known for over a hundred years, but is only now
becoming widely used. Originally developed as a tumor therapy, some of its most successful …

The course of immune stimulation by photodynamic therapy: bridging fundamentals of photochemically induced immunogenic cell death to the enrichment of T‐cell …

S Nath, G Obaid, T Hasan - Photochemistry and photobiology, 2019 - Wiley Online Library
Photodynamic therapy (PDT) is a potentially immunogenic and FDA‐approved antitumor
treatment modality that utilizes the spatiotemporal combination of a photosensitizer, light and …

The photobiology of photodynamic therapy: cellular targets and mechanisms

NL Oleinick, HH Evans - Radiation research, 1998 - meridian.allenpress.com
Photodynamic therapy (PDT) is dependent on the uptake of a photosensitizing dye, often a
porphyrin-related macrocycle, by the tumor or other abnormal tissue that is to be treated, the …

Intracellular signaling mechanisms in photodynamic therapy

RD Almeida, BJ Manadas, AP Carvalho… - Biochimica et Biophysica …, 2004 - Elsevier
In photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of
tumor cells and in the treatment of certain noncancerous conditions. Cell death in PDT may …