There have been many chapters written about macrophage polarization. These chapters
generally focus on the role of macrophages in orchestrating immune responses by …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …

Adenosine is a ubiquitous endogenous modulator with the main function of maintaining
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …

Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …

In recent years, researchers have devoted much attention to the diverse roles of
macrophages and their contributions to tissue development, wound healing, and …

Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …

Interleukin‐10 (IL‐10) has long been recognized to have potent and broad‐spectrum anti‐
inflammatory activity, which has been unequivocally established in various models of …

Adenosine, a nucleoside derived primarily from the extracellular hydrolysis of adenine
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …