The endothelium, inner layer of blood vessels, constitutes a metabolically active paracrine,
endocrine, and autocrine organ, able to sense the neighboring environment and exert a …

Background: Cardiovascular health (CVH) from young adulthood is strongly associated with
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …

Disruption of sphingolipid homeostasis and signaling has been implicated in diabetes,
cancer, cardiometabolic, and neurodegenerative disorders. Yet, mechanisms governing …

Anthracycline-induced cardiomyopathy is a leading cause of late morbidity in childhood
cancer survivors. Aberrant DNA methylation plays a role in de novo cardiovascular disease …

Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases
(CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility …

Importance Self-identified Black race is associated with higher hypertension prevalence and
worse blood pressure (BP) control compared with other race/ethnic groups. The contribution …

Background The development of coronary artery disease (CAD) is influenced by sex and
genetic factors. Genome-wide association studies (GWAS) have linked genetic loci to CAD …

Despite great progress in understanding lipoprotein physiology, there is still much to be
learned about the genetic drivers of lipoprotein abundance, composition, and function. We …

Aims The nuclear factor-κB (NF-κB) signalling pathway plays a critical role in the
pathogenesis of multiple vascular diseases. However, in endothelial cells (ECs), the …

An improved approach for predicting the risk for incident coronary heart disease (CHD)
could lead to substantial improvements in cardiovascular health. Previously, we have shown …