Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …

Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of
oncogene products or tumour suppressors is likely to be involved in the aetiology of …

Background & Aims Little is known about factors that promote gastric carcinogenesis. We
analyzed multiple microarray data sets for messenger RNAs (mRNAs) that were increased …

The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

The TRIM family is composed of multidomain ubiquitin E3 ligases characterized by the
presence of the N‐terminal tripartite motif (RING, B‐boxes, and coiled coil). TRIM proteins …

Background—Diabetic cardiomyopathy, which contributes to> 50% diabetic death, is
featured by myocardial lipid accumulation, hypertrophy, fibrosis, and cardiac dysfunction …

Some members of the tripartite motif (TRIM/RBCC) protein family are thought to be important
regulators of carcinogenesis. This is not surprising as the TRIM proteins are involved in …

The tripartite motif (TRIM) family is defined by the presence of a Really Interesting New Gene
(RING) domain, one or two B-box motifs and a coiled-coil region. TRIM proteins play key …

Selective autophagy entails cooperation between target recognition and assembly of the
autophagic apparatus. Target recognition is conducted by receptors that often recognize …

Growth hormone (GH) excess in acromegaly is associated with increased precancerous
colon polyps and soft tissue adenomas, whereas short-stature humans harboring an …