▪ Abstract Tissue development, differentiation, and physiology require specialized cellular
adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether …

Neurotransmitter receptor movement into and out of synapses is one of the core
mechanisms for rapidly changing the number of functional receptors during synaptic …

Synapses are found in vast numbers in the brain and contain complex proteomes. We
developed genetic labeling and imaging methods to examine synaptic proteins in individual …

Trafficking of AMPA receptors (AMPA-Rs) to and from synapses controls the strength of
excitatory synaptic transmission. However, proteins that cluster AMPA-Rs at synapses …

The origins and evolution of higher cognitive functions, including complex forms of learning,
attention and executive functions, are unknown. A potential mechanism driving the evolution …

Correct establishment and maintenance of cell polarity is required for the development and
homeostasis of all metazoans. Cell-polarity mechanisms are responsible not only for the …

Dendritic spines are small protrusions that cover the surface of dendrites and bear the
postsynaptic component of excitatory synapses. Having an enlarged head connected to the …

The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses.
Recent studies have provided interesting insights into several aspects of the trafficking of …

Synaptic transmission underlies every aspect of brain function. Excitatory synapses, which
release the neurotransmitter glutamate, are the most numerous type of synapse in the brain …

Abstract Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily
conserved components of a common genetic pathway that link the seemingly disparate …