Immune checkpoint regulators are critical modulators of the immune system, allowing the
initiation of a productive immune response and preventing the onset of autoimmunity. Co …

As a cause of postoperative complications and early hepatic failure after liver
transplantation, liver ischemia/reperfusion injury (IRI) still has no effective treatment during …

Breast cancer remains a significant global health challenge, and its mechanisms of
progression and metastasis are still not fully understood. In this study, analysis of TCGA and …

Background Overexpression of membranous CD154 in T lymphocytes has been found
previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has …

Physicians should be knowledgeable regarding several aspects of autoimmune disorders,
especially systemic lupus erythematosus (SLE), with which patients can present in their …

Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to
mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory …

Objective Lupus nephritis (LN) is a major determinant of morbidity and mortality in systemic
lupus erythematosus (SLE). Pim‐1 regulates lymphocyte proliferation and activation. The …

Gene transfer into primary human CD4 T lymphocytes is a critical tool in studying the
mechanism of T cell-dependent immune responses and human immunodeficiency virus-1 …

Objective Systemic lupus erythematosus (SLE) T cells display a hyperactive calcineurin/NF‐
AT pathway. The aim of this study was to determine whether this pathway is responsible for …

Introduction The kidney biopsy is used to diagnose and guide initial therapy in patients with
lupus nephritis (LN). Kidney histology does not correlate well with clinical measurements of …