Directed evolution drives the next generation of biocatalysts

NJ Turner - Nature chemical biology, 2009 - nature.com
Enzymes are increasingly being used as biocatalysts in the generation of products that have
until now been derived using traditional chemical processes. Such products range from …

Hydrolases: catalytically promiscuous enzymes for non-conventional reactions in organic synthesis

E Busto, V Gotor-Fernández, V Gotor - Chemical Society Reviews, 2010 - pubs.rsc.org
During the last three decades the use of hydrolases for the catalysis of environmentally
friendly organic processes under mild reaction conditions has been well documented …

Enzyme immobilization in porphyrinic covalent organic frameworks for photoenzymatic asymmetric catalysis

C Jin, N Li, E Lin, X Chen, T Wang, Y Wang… - ACS …, 2022 - ACS Publications
Integrating photocatalysis and biocatalysis to fabricate photobiocatalysts for asymmetric
catalysis is of great significance but remains challenging. In this work, we build a …

E factors, green chemistry and catalysis: an odyssey

RA Sheldon - Chemical Communications, 2008 - pubs.rsc.org
The development of green chemistry is traced from the introduction of the concepts of atom
economy (atom utilisation) and E factors in the early 1990s. The important role of catalysis in …

Concurrent asymmetric reactions combining photocatalysis and enzyme catalysis: direct enantioselective synthesis of 2, 2‐disubstituted indol‐3‐ones from 2 …

X Ding, CL Dong, Z Guan, YH He - Angewandte Chemie, 2019 - Wiley Online Library
The combination of photoredox and enzymatic catalysis for the direct asymmetric one‐pot
synthesis of 2, 2‐disubstituted indol‐3‐ones from 2‐arylindoles through concurrent …

Functional analysis of a predicted flavonol synthase gene family in Arabidopsis

DK Owens, AB Alerding, KC Crosby… - Plant …, 2008 - academic.oup.com
Abstract The genome of Arabidopsis (Arabidopsis thaliana) contains five sequences with
high similarity to FLAVONOL SYNTHASE1 (AtFLS1), a previously characterized flavonol …

Biocatalytic promiscuity

MS Humble, P Berglund - European Journal of Organic …, 2011 - Wiley Online Library
Enzymes are attractive catalysts because of their promiscuity and their ability to perform
highly regio‐, chemo‐and stereoselective transformations. Enzyme promiscuity allows …

Design of artificial enzymes bearing several active centers: New trends, opportunities and problems

D Carballares, R Morellon-Sterling… - International Journal of …, 2022 - mdpi.com
Harnessing enzymes which possess several catalytic activities is a topic where intense
research has been carried out, mainly coupled with the development of cascade reactions …

De novo active sites for resurrected Precambrian enzymes

VA Risso, S Martinez-Rodriguez, AM Candel… - Nature …, 2017 - nature.com
Protein engineering studies often suggest the emergence of completely new enzyme
functionalities to be highly improbable. However, enzymes likely catalysed many different …

Asymmetric oxidative Mannich reactions promoted by photocatalysis and electrochemistry

CJ Long, YH He, Z Guan - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
The asymmetric Mannich reaction is an essential method in contemporary organic
chemistry. As a representative of clean and green synthesis methods, photochemical and …