Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

In the past two decades, drug candidates with a covalent binding mode have gained the
interest of medicinal chemists, as several covalent anticancer drugs have successfully …

Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease
(PD), which is caused by excessive iron accumulation in the intracellular labile iron pool …

Parkinson's disease (PD), a progressive neurodegenerative movement disorder, has
reached pandemic status worldwide. This neurologic disorder is caused primarily by the …

Cyanamides have emerged as privileged scaffolds in covalent inhibitors of deubiquitinating
enzymes (DUBs). However, many compounds with a cyanopyrrolidine warhead show cross …

The nucleus controls cell growth and division through coordinated interactions between
nuclear proteins and chromatin. Mutations that impair nuclear protein association with …

The integration of diverse chemical tools like small-molecule inhibitors, activity-based
probes (ABPs), and proteolysis targeting chimeras (PROTACs) advances clinical drug …

Neurodegenerative diseases (NDs) are one of the prominent health challenges facing
contemporary society, and many efforts have been made to overcome and (or) control it. In …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive loss of dopaminergic (DA) neurons in the substantia nigra region of the …

Abstract Ethnopharmacological relevance Celastrus orbiculatus Thunb. is an ancient
traditional Chinese herb with a long history of medicinal use. The ethyl acetate extract of …