Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Dysregulated maternal nutrition, such as vitamin deficiencies and excessive levels of
glucose and fatty acids, increases the risk for congenital heart disease (CHD) in the …

Insufficient oxygen supply (hypoxia) during fetal development leads to cardiac remodeling
and a predisposition to cardiovascular disease in later life. Previous work has shown …

The obesity epidemic has led to more women entering pregnancy overweight or obese. In
addition to adverse short‐term outcomes, maternal obesity and/or gestational diabetes …

Research on mechanisms underlying the phenomenon of developmental programming of
health and disease has focused primarily on processes that are specific to cell types, organs …

Globally, cardiovascular disease remains the leading cause of death. Most concerning is the
rise in cardiovascular risk factors including obesity, diabetes and hypertension among youth …

Embryonic and foetal development are critical periods of development in which several
environmental cues determine health and disease in adulthood. Maternal conditions and an …

Dysregulated maternal fatty acid metabolism increases the risk of congenital heart disease
(CHD) in offspring with an unknown mechanism, and the effect of folic acid fortification in …

Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal
cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and …