Dengue: update on clinically relevant therapeutic strategies and vaccines

M Palanichamy Kala, AL St. John… - Current Treatment Options …, 2023 - Springer
Opinion statement Dengue viruses (DENV) continue to circulate worldwide, resulting in a
significant burden on human health. There are four antigenically distinct serotypes of DENV …

Dengue: A focused review for the emergency clinician

MJ Pajor, B Long, SY Liang - The American Journal of Emergency …, 2024 - Elsevier
Dengue is an arbovirus transmitted by the Aedes spp. mosquito. Approximately 390 million
infections occur annually per World Health Organization estimates, with significant increases …

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

O Goethals, SJF Kaptein, B Kesteleyn, JF Bonfanti… - Nature, 2023 - nature.com
Dengue is a major health threat and the number of symptomatic infections caused by the
four dengue serotypes is estimated to be 96 million with annually around 10,000 deaths …

Antiviral agents against flavivirus protease: prospect and future direction

SK Samrat, J Xu, Z Li, J Zhou, H Li - Pathogens, 2022 - mdpi.com
Flaviviruses cause a significant amount of mortality and morbidity, especially in regions
where they are endemic. A recent example is the outbreak of Zika virus throughout the …

Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases

YS Li, HC Ren, JH Cao - International Immunopharmacology, 2022 - Elsevier
Abstract Interleukin-6 (IL-6) is a highly pleiotropic glycoprotein factor that can modulate
innate and adaptive immunity as well as various aspects of metabolism, including glycolysis …

Dengue virus infection and neurological manifestations: an update

SL Fong, KT Wong, CT Tan - Brain, 2024 - academic.oup.com
Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes
albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in …

Nanoparticles and Antiviral Vaccines

S Liu, M Hu, X Liu, X Liu, T Chen, Y Zhu, T Liang… - Vaccines, 2023 - mdpi.com
Viruses have threatened human lives for decades, causing both chronic and acute infections
accompanied by mild to severe symptoms. During the long journey of confrontation, humans …

Preparedness for the dengue epidemic: vaccine as a Viable approach

M Zeyaullah, K Muzammil, AM AlShahrani, N Khan… - Vaccines, 2022 - mdpi.com
Dengue fever is one of the significant fatal mosquito-borne viral diseases and is considered
to be a worldwide problem. Aedes mosquito is responsible for transmitting various serotypes …

Antiviral activity of flavonoids from Geopropolis of the Brazilian Jandaira bee against zika and dengue viruses

PG Silva, EJF Chaves, TMS Silva, GB Rocha… - Pharmaceutics, 2023 - mdpi.com
Arthropod-borne viruses within the Flaviviridae family such as Zika (ZIKV) and dengue
(DENV) are responsible for major outbreaks in tropical countries, and there are no specific …

Mechanistic insights into bone remodelling dysregulation by human viral pathogens

CCS Caetano, T Azamor, NM Meyer… - Nature …, 2024 - nature.com
Bone-related diseases (osteopathologies) associated with human virus infections have
increased around the globe. Recent findings have highlighted the intricate interplay …