Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

In eukaryotic cells, mRNAs are exquisitely controlled, often through regulatory elements in
their 3′ untranslated regions (3′ UTRs). Proteins that bind to those sites are key players in …

Germline stem cells play a pivotal role in gametogenesis; yet little is known about how they
are formed, how they divide to self-renew, and how these processes are genetically …

Stem cells are thought to occupy special local environments, or niches, established by
neighboring cells that give them the capability for self-renewal. Each ovariole in the …

Puf proteins are developmental regulators that control mRNA stability and translation by
binding sequences in the 3′ untranslated regions of their target mRNAs. We have …

To understand how homeotic genes affect morphogenesis and differentiation, their target
genes must be identified. In Arabidopsis flowers, the homeotic protein heterodimer …

Background: Morphogenetic movements are closely regulated by the expression of
developmental genes. Here I examine whether developmental gene expression can in turn …

The NF-κB-like Relish gene is complex, with four transcripts that are all located within an
intron of the Nmdmc gene. Using deletion mutants, we show that Relish is specifically …

The nematode Caenorhabditis elegans has two sexes, males and hermaphrodites.
Hermaphrodites initially produce sperm but switch to producing oocytes. This switch …

The zinc-finger protein Nanos and the RNA-binding protein Pumilio act together to repress
the translation of maternal hunchback RNA in the posterior of the Drosophila embryo …