Novel approaches used to examine and control neurogenesis in Parkinson′ s disease

AB Salmina, MR Kapkaeva, AS Vetchinova… - International Journal of …, 2021 - mdpi.com
Neurogenesis is a key mechanism of brain development and plasticity, which is impaired in
chronic neurodegeneration, including Parkinson's disease. The accumulation of aberrant α …

Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?

N Geribaldi-Doldán, L Carrascal… - International journal of …, 2023 - mdpi.com
Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific
neurogenic niches, which generate neurons from neural stem cells as a homeostatic …

Mitochondrial dysfunction in dopaminergic neurons derived from patients with LRRK2-and SNCA-associated genetic forms of Parkinson's disease

AS Vetchinova, MR Kapkaeva, MV Ivanov… - Current Issues in …, 2023 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease. Some
cases of PD may be caused by genetic factors, among which mutations in the LRRK2 and …

Current state-of-the-art and unresolved problems in using human induced pluripotent stem cell-derived dopamine neurons for parkinson's disease drug development

SA Antonov, EV Novosadova - International Journal of Molecular …, 2021 - mdpi.com
Human induced pluripotent stem (iPS) cells have the potential to give rise to a new era in
Parkinson's disease (PD) research. As a unique source of midbrain dopaminergic (DA) …

The role of Hippo signaling pathway in the development of the nervous system

X Li, K Li, Y Chen, F Fang - Developmental neuroscience, 2021 - karger.com
Hippo signaling pathway is a highly conserved and crucial signaling pathway that controls
the size of tissues and organs by regulating the proliferation, differentiation, and apoptosis of …

Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson's disease

F Wang, XY Cheng, YT Zhang, QR Bai… - Open Life …, 2024 - degruyter.com
Parkinson's disease (PD) is a ubiquitous brain cell degeneration disease and presents a
significant therapeutic challenge. By injecting 6-hydroxydopamine (6-OHDA) into the left …

Overexpression of Parkin in the Neuronal Progenitor Cells from a Patient with Parkinson's Disease Shifts the Transcriptome Towards the Normal State

O Lebedeva, D Poberezhniy, E Novosadova… - Molecular …, 2023 - Springer
Parkinson's disease (PD) is a neurodegenerative pathology caused by the progressive loss
of dopaminergic neurons in the substantia nigra. Juvenile PD is known to be strongly …

Transcription of HOX Genes Is Significantly Increased during Neuronal Differentiation of iPSCs Derived from Patients with Parkinson's Disease

VB Fedoseyeva, EV Novosadova… - Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is the most serious movement disorder, but the actual cause of this
disease is still unknown. Induced pluripotent stem cell-derived neural cultures from PD …

Activation of Embryonic Gene Transcription in Neural Precursor Cells Derived from the Induced Pluripotent Stem Cells of the Patients with Parkinson's Disease

VB Fedoseyeva, EV Novosadova, VV Nenasheva… - Biochemistry …, 2023 - Springer
Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the
world. Despite numerous studies, the causes of this pathology remain completely unknown …

Relationship Between the rs6265 Polymorphism of the BDNF Gene and the Serum Neurotrophic Factor Level in Patients with Parkinson's Disease

MA Nikitina, EY Bragina, MS Nazarenko… - Neuroscience and …, 2024 - Springer
Objectives. To evaluate clinical features and serum brain-derived neurotrophic factor
(BDNF) levels in groups of patients with Parkinson's disease (PD) with different genotypes of …