A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk

M Izmirli - Molecular biology reports, 2013 - Springer
Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate
metabolism. This enzyme is mapped on chromosome 1, which is located at the end of the …

[HTML][HTML] Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibility

P Kumar, U Yadav, V Rai - Meta Gene, 2015 - Elsevier
There are several evidences supporting the role of 5–10 methylenetetrahydrofolate
reductase (MTHFR) gene polymorphisms in breast cancer (BC). Case control association …

The association between MTHFR polymorphism and cervical cancer

JM Gong, Y Shen, WW Shan, YX He - Scientific reports, 2018 - nature.com
Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was
to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) …

Looking for drugs in all the wrong places: use of GCPII inhibitors outside the brain

JJ Vornov, D Peters, M Nedelcovych, K Hollinger… - Neurochemical …, 2020 - Springer
In tribute to our friend and colleague Michael Robinson, we review his involvement in the
identification, characterization and localization of the metallopeptidase glutamate …

Structural and biochemical characterization of the folyl‐poly‐γ‐l‐glutamate hydrolyzing activity of human glutamate carboxypeptidase II

M Navrátil, J Ptáček, P Šácha, J Starková… - The FEBS …, 2014 - Wiley Online Library
In addition to its well‐characterized role in the central nervous system, human glutamate
carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small …

Association of MTHFR (C677T) Gene Polymorphism with Breast Cancer in North India

M Waseem, SR Hussain, S Kumar… - Biomarkers in …, 2016 - journals.sagepub.com
Background Breast cancer is one of the most common malignancies in women and is
associated with a variety of risk factors. The functional single-nucleotide polymorphism …

[HTML][HTML] Association of MTRR A66G polymorphism with cancer susceptibility: Evidence from 85 studies

P Wang, S Li, M Wang, J He, S Xi - Journal of cancer, 2017 - ncbi.nlm.nih.gov
Methionine synthase reductase (MTRR) is a key regulatory enzyme involved in the folate
metabolic pathway. Previous studies investigating the association of MTRR A66G …

The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations

V Rai - Asian Pacific Journal of Cancer Prevention, 2014 - koreascience.kr
Background: Methylenetetrahydrofolate (MTHFR) is the key enzyme of the folate metabolic
pathway and several studies have pointed to association between the MTHFR C677T …

Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women

B Lajin, A Alhaj Sakur, L Ghabreau, A Alachkar - Tumor Biology, 2012 - Springer
Dietary folate status as well as polymorphisms in one-carbon metabolism genes may affect
the risk of breast cancer through aberrant DNA methylation and altered nucleotide synthesis …

MTHFR 677C> T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controls

S Pooja, J Carlus, D Sekhar, A Francis, N Gupta… - PLoS …, 2015 - journals.plos.org
Background Methylenetetrahydrofolate reductase (MTHFR) acts at an important metabolic
point in the regulation of cellular methylation reaction. It assists in the conversion of 5, 10 …