Despite standard hormonal therapy that targets the androgen receptor (AR) attenuates
prostate cancer (PCa) effectively in the initial stage, the tumor ultimately converts to …

Highlights•Tumor-immune CCIs can be investigated using scRNA-seq and ST
strategies.•CCI studies elucidate fundamental mechanisms in disease state.•Open-source …

Newly growing evidence highlights the essential role that epitranscriptomic marks play in the
development of many cancers; however, little is known about the role and implications of …

Immunotherapy has received widespread attention for its effective and long‐term tumor‐
eliminating ability. However, for immunogenic “cold” tumors, such as prostate cancer (PCa) …

Neurotransmitters are key modulators in neuro-immune circuits and have been linked to
tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor …

Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …

In recent years, advancements in single-cell and spatial transcriptomics, which are highly
regarded developments in the current era, particularly the emerging integration of single-cell …

Introduction Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types in
tumor microenvironment. However, the phenotypic and functional heterogeneities among …

Macrophages are the main component of the tumor microenvironment, which are
differentiated from monocytes in the blood and play an important role in cancer …

BACKGROUND Mammalian reproduction requires the fusion of two specialized cells: an
oocyte and a sperm. In addition to producing gametes, the reproductive system also …