Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …

The interindividual genetic variations in drug metabolizing enzymes and transporters
influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision …

ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …

The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins,
which transport a variety of compounds through the membrane against a concentration …

Objective The antiplatelet activity of clopidogrel is characterized by considerable
interindividual differences. Variable intestinal absorption is suggested to contribute to the …

A variety of drug transporters expressed in the body control the fate of drugs by affecting
absorption, distribution, and elimination processes. In the small intestine, transporters …

A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …

Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …