Current challenges in the development of vaccines for pneumonic plague

ST Smiley - Expert review of vaccines, 2008 - Taylor & Francis
Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and
exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we …

A historical review of military medical strategies for fighting infectious diseases: From battlefields to global health

R Biselli, R Nisini, F Lista, A Autore, M Lastilla… - Biomedicines, 2022 - mdpi.com
The environmental conditions generated by war and characterized by poverty,
undernutrition, stress, difficult access to safe water and food as well as lack of environmental …

Immune defense against pneumonic plague

ST Smiley - Immunological reviews, 2008 - Wiley Online Library
Yersinia pestis is one of the world's most virulent human pathogens. Inhalation of this Gram‐
negative bacterium causes pneumonic plague, a rapidly progressing and usually fatal …

Mutated and Bacteriophage T4 Nanoparticle Arrayed F1-V Immunogens from Yersinia pestis as Next Generation Plague Vaccines

P Tao, M Mahalingam, ML Kirtley, CJ van Lier… - PLoS …, 2013 - journals.plos.org
Pneumonic plague is a highly virulent infectious disease with 100% mortality rate, and its
causative organism Yersinia pestis poses a serious threat for deliberate use as a bioterror …

Encapsulation into amphiphilic polyanhydride microparticles stabilizes Yersinia pestis antigens

B Carrillo-Conde, E Schiltz, J Yu, FC Minion… - Acta biomaterialia, 2010 - Elsevier
The design of biodegradable polymeric delivery systems based on polyanhydrides that
would provide for improved structural integrity of Yersinia pestis antigens was the main goal …

Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis

CE Chandler, EM Harberts… - Proceedings of the …, 2020 - National Acad Sciences
Immune evasion through membrane remodeling is a hallmark of Yersinia pestis
pathogenesis. Yersinia remodels its membrane during its life cycle as it alternates between …

Single-dose combination nanovaccine induces both rapid and long-lived protection against pneumonic plague

DA Wagner, SM Kelly, AC Petersen, N Peroutka-Bigus… - Acta biomaterialia, 2019 - Elsevier
Yersinia pestis, the causative agent of pneumonic plague, induces a highly lethal infection if
left untreated. Currently, there is no FDA-approved vaccine against this pathogen; however …

Plague prevention and therapy: perspectives on current and future strategies

R Rosario-Acevedo, SS Biryukov, JA Bozue, CK Cote - Biomedicines, 2021 - mdpi.com
Plague, caused by the bacterial pathogen Yersinia pestis, is a vector-borne disease that has
caused millions of human deaths over several centuries. Presently, human plague infections …

Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens

S Uddowla, LC Freytag, JD Clements - Vaccine, 2007 - Elsevier
In this study, we compare four different adjuvants, LT (R192G), CpG ODN, MPL® TDM, and
alum, for their ability to affect the magnitude, distribution, and duration of antibody responses …

A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs

VA Feodorova, LN Pan'kina, EP Savostina… - Vaccine, 2007 - Elsevier
The lpxM mutant of the live vaccine Yersinia pestis EV NIIEG strain synthesising a less toxic
penta-acylated lipopolysaccharide was found to be avirulent in mice and guinea pigs …