Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed
in COVID-19. However, it is unclear whether SARS-CoV-2 replicates in the human intestine …

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-
dimensional in vitro human distal lung culture systems would strongly facilitate the …

Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Human epithelial organoids—3D spheroids derived from adult tissue stem cells—enable
investigation of epithelial physiology and disease and host interactions with …

Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …

Three-dimensional hydrogel-based organ-like cultures can be applied to study
development, regeneration, and disease in vitro. However, the control of engineered …