One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by
an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives …

As our understanding of the mechanisms of cancer treatment has increased, a growing
number of studies demonstrate pathways through which DNA damage repair (DDR) affects …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Radiation therapy (RT) is a standard treatment for solid tumors and about 50% of patients
with cancer, including pediatric cancer, receive RT. While RT has significantly improved the …

DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …

Since the evolution of the aerobic metabolism, reactive oxygen species (ROS) have
represented significant challenges to diverse life forms. In recent decades, increasing …

Upon solid organ transplantation and during cancer immunotherapy, cellular stress
responses result in the release of damage-associated molecular patterns (DAMPs). The …

Background Although the prognosis for most patients with papillary thyroid cancer (PTC) is
good, the present treatment is ineffective for 5–10% patients. Several studies found sodium …

Cancer is a death cause in economically developed countries that results growing also in
developing countries. Improved outcome through targeted interventions faces the scarce …

Tire wear particles (TWPs) have caused increasing concerns due to their detrimental effects
on the soil ecosystem. However, the role of weathering in altering the toxicity of TWP to soil …