Organophosphorus compounds (OP) are a constant problem, both in the military and in the
civilian field, not only in the form of acute poisoning but also for their long-lasting …

Organophosphorus (OPs) compounds are widely used as insecticides, plasticizers, and fuel
additives. These compounds potently inhibit acetylcholinesterase (AChE), the enzyme that …

Central nervous system (CNS) disorders represent one of the leading causes of global
health burden. Nonetheless, new therapies approved against these disorders are among …

Cationic bovine serum albumin (CBSA) conjugated poly (ethyleneglycol)-poly (lactide)(PEG-
PLA) nanoparticle (CBSA-NP), was designed as a novel drug carrier for brain delivery. In …

The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (BECs)
supported by pericytes and astrocytes. The BBB maintains homeostasis and protects the …

The neurotoxicity of triphenyl phosphate (TPHP) in exposed humans and laboratory animals
is under debate. The rapid crossing of the blood-brain barrier (BBB) and high distribution of …

The exposure to environmental stressors, such as organophosphate (OP) pesticides, has
been associated with the development of neurodegenerative diseases. Chlorpyrifos (CPF) is …

Exposure to organophosphate (OP) insecticides has been related to several adverse health
effects, including neurotoxicity. The primary insecticidal mode of action of OP insecticides …

The discovery and development of a new drug are time-consuming, difficult and expensive.
This complex process has evolved from classical methods into an integration of modern …

Chlorpyrifos (CPF) is the most frequently applied insecticide. Aside from effects on the
neuronal cholinergic system, previous studies suggested a potential relationship between …