Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers

P Freund, M Seif, N Weiskopf, K Friston… - The Lancet …, 2019 - thelancet.com
Traumatic spinal cord injury occurs when an external physical impact damages the spinal
cord and leads to permanent neurological dysfunction and disability, and it is associated …

[HTML][HTML] Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2

FH Brennan, T Jogia, ER Gillespie, LV Blomster, XX Li… - JCI insight, 2019 - ncbi.nlm.nih.gov
Traumatic spinal cord injury (SCI) triggers an acute-phase response that leads to systemic
inflammation and rapid mobilization of bone marrow (BM) neutrophils into the blood. These …

CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice

SN Shaikh, EF Willis, M Dierich, Y Xu… - Journal of …, 2023 - Springer
Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic
haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in …

Cervical cord neurodegeneration in traumatic and non-traumatic spinal cord injury

M Seif, G David, E Huber, K Vallotton, A Curt… - Journal of …, 2020 - liebertpub.com
This study aimed to compare macrostructural and microstructural neurodegenerative
changes remote from a cervical spinal cord injury in traumatic spinal cord injury (tSCI) and …

Perfusion imaging metrics after acute traumatic spinal cord injury are associated with injury severity in rats and humans

ZZ Khaing, J Leyendecker, JN Harmon… - Science Translational …, 2024 - science.org
Traumatic spinal cord injury (tSCI) causes an immediate loss of neurological function, and
the prediction of recovery is difficult in the acute phase. In this study, we used contrast …

Longitudinal diffusion tensor imaging in frontotemporal dementia

CJ Mahoney, IJA Simpson, JM Nicholas… - Annals of …, 2015 - Wiley Online Library
Objective Novel biomarkers for monitoring progression in neurodegenerative conditions are
needed. Measurement of microstructural changes in white matter (WM) using diffusion …

[HTML][HTML] Predicting pain relief: use of pre-surgical trigeminal nerve diffusion metrics in trigeminal neuralgia

PSP Hung, DQ Chen, KD Davis, J Zhong, M Hodaie - NeuroImage: Clinical, 2017 - Elsevier
Trigeminal neuralgia (TN) is a chronic neuropathic facial pain disorder that commonly
responds to surgery. A proportion of patients, however, do not benefit and suffer ongoing …

Dorsal and ventral horn atrophy is associated with clinical outcome after spinal cord injury

E Huber, G David, AJ Thompson, N Weiskopf… - Neurology, 2018 - AAN Enterprises
Objective To investigate whether gray matter pathology above the level of injury, alongside
white matter changes, also contributes to sensorimotor impairments after spinal cord injury …

Extent of cord pathology in the lumbosacral enlargement in non-traumatic versus traumatic spinal cord injury

G David, K Vallotton, M Hupp, A Curt… - Journal of …, 2022 - liebertpub.com
This study compares remote neurodegenerative changes caudal to a cervical injury in
degenerative cervical myelopathy (DCM; ie, non-traumatic) and incomplete traumatic spinal …