Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human
African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in …

Leishmaniasis is a complex of neglected tropical diseases caused by various species of
leishmanial parasites that primarily affect the world's poorest people. A limited number of …

Background Visceral leishmaniasis (VL), caused by the protozoan parasite Leishmania
donovani (L. donovani), is the most severe form of leishmaniasis. It is largely responsible for …

Leishmaniasis is a zoonotic disease transmitted by an obligate intra-macrophage protozoan
of the genus Leishmania through the infective bite of a vector sandfly. This study …

Since the beginning of the XXI century, Leishmaniasis has been integrated into the World
Health Organization's list of the 20 neglected tropical diseases, being considered a public …

Glutamine synthetase (GS) is one of the most important metabolic enzymes which catalyzes
ligation of glutamate and ammonia to form glutamine. Previous studies from our lab had …

Chagas disease, caused by the parasite Trypanosoma cruzi, is an infectious illness endemic
to Latin America and still lacks an effective treatment for the chronic stage. In a previous …

In the current work, sixteen novel amide derivatives of phenanthridine were designed and
synthesized using 9-fluorenone, 4-Methoxy benzyl amine, and alkyl/aryl acids. The …

Repurposing drugs and adjuvants is an attractive choice of present therapy that reduces the
substantial costs, chances of failure, and systemic toxicity. Mycobacterium indicus pranii was …

The development of new molecules for the treatment of leishmaniasis is, a neglected
parasitic disease, is urgent as current anti-leishmanial therapeutics are hampered by drug …