Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological
mechanisms,(ii) an inverse correlation between their incidences, and (iii) oxidative stress …

Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

Cysteine sulfinic acid or S-sulfinylation is an oxidative post-translational modification
(OxiPTM) that is known to be involved in redox-dependent regulation of protein function but …

Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22‑27 kDa) non‑
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …

Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are
accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of …

Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to
balance cellular hydrogen peroxide (H 2 O 2) levels, which are essential for cell signaling …

Caloric restriction (CR) extends the lifespan of flies, worms, and yeast by counteracting age-
related oxidation of H 2 O 2-scavenging peroxiredoxins (Prxs). Here, we show that …

抄録 Peroxiredoxins possess thioredoxin or glutathione peroxidase and chaperone-like
activities and thereby protect cells from oxidative insults. Recent studies, however, reveal …