Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

Monomeric serum immunoglobulin A (IgA) can contribute to the development of various
autoimmune diseases, but the regulation of serum IgA effector functions is not well defined …

Most infectious agents enter the body at mucosal surfaces and therefore mucosal immune
responses function as a first line of defence. Protective mucosal immune responses are most …

In mammals, the gastrointestinal tract harbors an extraordinarily dense and complex
community of microorganisms. The gut microbiota provide strong selective pressure to the …

The intestinal cell types responsible for defense against pathogenic organisms remain
incompletely characterized. Here we identify a subset of CD11chiCD11bhi lamina propria …

Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In
this review, we summarize recent advances in our understanding of the sites, mechanisms …

The IgA receptor family comprises a number of surface receptors including the polymeric Ig
receptor involved in epithelial transport of IgA/IgM, the myeloid specific IgA Fc receptor …

Differing from humans, IgG from breast milk in many animal species (rodents, bovines, cats,
ferrets, etc.) are transported across the intestinal epithelium into the neonatal circulation …

Mass spectrometry–based glycoproteomics has gone through some incredible
developments over the last few years. Technological advances in glycopeptide enrichment …