T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …

Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …

Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive
malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP …

CD4+ T cells are critical for host defense but are also major drivers of immune-mediated
disease. These T cells specialize to become distinct subsets and produce restricted patterns …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy and
new therapeutics are much needed. Profiling patient leukemia drug sensitivities ex vivo, we …