Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

NMDA receptors comprised of different NR2 subunits exhibit strikingly unique biophysical
and pharmacological properties. Here, we report that the extracellular amino-terminal …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that play key roles in
synaptic transmission and plasticity. Both hyper‐and hypo‐activation of NMDARs are …

Fast synaptic neurotransmission in the vertebrate central nervous system relies primarily on
ionotropic glutamate receptors (iGluRs), which drive neuronal excitation, and type A γ …

Abstract d-Serine (d-Ser) is an endogenous co-agonist for NMDA receptors and regulates
neurotransmission and synaptic plasticity in the forebrain. d-Ser is also found in the …

Ionotropic glutamate receptor (iGluR) family members are integrated into supramolecular
complexes that modulate their location and function at excitatory synapses. However, a lack …

D-amino acid oxidase (DAO) is a flavoenzyme that metabolizes certain D-amino acids,
notably the endogenous N-methyl D-aspartate receptor (NMDAR) co-agonist, D-serine. As …

Ionotropic glutamate receptors (iGluRs) are a major class of ligand‐gated ion channels that
are widespread in the living kingdom. Their critical role in excitatory neurotransmission and …

d-Serine is a unique endogenous substance enriched in the brain at the exceptionally high
concentrations as a free d-amino acid in mammals throughout their life. Peripheral tissues …